State-of-the-Art Reviews

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AORTA, August 2015, Volume 3, Issue 4:122-135
DOI: 10.12945/j.aorta.2015.14.062

Open Stented Grafts for Frozen Elephant Trunk Technique: Technical Aspects and Current Outcomes

Wei-Guo Ma, MD1,2, Jun Zheng, MD1, Li-Zhong Sun, MD1*, John A. Elefteriades, MD2

1 Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, and Beijing Engineering Research Center of Vascular Prostheses, Beijing, China

2 Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, Connecticut, USA


With growing experience in patients with aneurysms and dissections in the arch and proximal descending aorta, the frozen elephant trunk (FET) technique has been shown to be safe and effective, and has achieved favorable short to mid-term outcomes.  As the FET technique is gaining wider acceptance, there is a growing need for versatile, technically simple, and highly durable open-stented grafts involving less complicated deployment mechanisms enabling use in various indications.  This paper gives a brief review on the technical aspects and clinical outcomes of currently available open-stented grafts used in the FET technique, including the E-vita Open Plus, Thoraflex Hybrid, Cronus, and J Graft.  While none of these grafts can claim to be an ideal device, technology continues to improve towards this goal.  As newer devices and systems are developed, more widespread use of the FET technique can be expected; such progress promises to improve the clinical outcomes and quality of life for patients with complex aortic diseases.

Diseases of the aortic arch and descending aorta remain among the great challenges in cardiovascular surgery. In March 1982, Dr. Hans-Georg Borst introduced the 2-stage elephant trunk technique in Hannover, Germany, which has greatly facilitated surgical treatment of this special pathologic entity [1]. Nevertheless, the cumulative risks of two major surgical procedures [24] stimulated further explorations aimed at achieving complete repair of extensive aortic lesions in one single operation [5, 6]. As the first in-human application of intraluminal stent graft for aortic aneurysms by Juan Parodi had fueled subsequent innovations [7], Dr. Kato proposed a modification to the classic elephant trunk technique [8] based on his early investigations [911], in which a covered endovascular stent graft is deployed into the descending aorta through the open aortic arch. The open stented graft (OSG) can be securely fixed at the desired level inside the distal descending aorta, allowing thrombus formation within the space between the graft and the aortic wall. The inventor of the elephant trunk technique, Hans-Georg Borst, named this approach the “frozen elephant trunk (FET)” [12], which has been increasing steadily in use since the late 1990s [1316].

With growing experience in patients with aneurysms and dissections of the arch and proximal descending aorta, the FET technique has been shown to be safe and effective, with favorable early and long-term outcomes [1624]. Accordingly, the FET technique is gaining wider acceptance among the cardiovascular surgical community, resulting in a growing need for open stent grafts. This paper aims to review briefly the currently available OSGs used in the FET technique, including the E-vita Open and Open Plus, Thoraflex Hybrid, Cronus, and J Graft open stent graft, with emphasis upon technical aspects and clinical outcomes.

Chavan-Haverich Prosthesis (Non-Commercial)

Designed by Drs. Chavan and Haverich again in Hannover, the custom-made endograft (Curative GmbH, Dresden, Germany) was the prosthesis for FET in the Hannover group before 2007 [25, 26]. It is composed of a proximal unstented Dacron tube and a distal stented tube with Z-shaped stainless steel stents affixed to the inner aspect (Figure 1) [27]. A 5-mm gap between the stents, maintained by two longitudinally oriented stainless steel wires, allows for flexibility of the graft. The stents are 30–46 mm in diameter and individually 22 mm in length. There may be three or four stents, depending on individual patient's size and anatomy.

Figure 1.

The Chavan-Haverich endograft [27] (Reprinted with permission from Springer).


The delivery system consists of a 39 French (F) outer sheath, a 34 F inner sheath and a central pusher [12, 2831]. It is introduced in an antegrade fashion into the descending aorta via a guide wire which is inserted transfemorally. Positioning may be determined with a C-arm or by measurements on preoperative CT scan. The outer sheath is withdrawn while the inner sheath and the pusher are held steady, and the stented portion will be deployed in the descending aorta. The proximal Dacron graft is released by pulling back both sheaths simultaneously while holding the pusher steady. Then the delivery system is extracted completely. The proximal unstented part is sutured circumferentially to the aorta distal to the origin of the left subclavian artery with 3-0 running polypropylene. The arch branches are anastomosed end-to-side to the Dacron graft as a Carrel patch [2831]. The initial tube graft was unsealed and bleeding was a serious issue. The sealant used in the later version reduced bleeding considerably, however the release of the graft from the delivery system became a problem due to adhesions. Hereafter, while further development was underway, the prosthesis was thus compressed and delivered with a special clamp shaped like a curved tube in two halves (Figure 2). Because the stented part is stiff and the clamp is 28 mm in diameter, it is difficult to implant especially in cases of acute Type A dissections and small descending aortas.

Figure 2.

Delivery of the Chavan-Haverich endograft (Courtesy of Dr. Maximilian Pichlmaier).


In a report by the Hannover group, the Chavan-Haverich prosthesis was implanted in 65 patients (17 acute dissection, 29 chronic dissection and 19 aneurysm) with a mean age of 61 ± 13 years. The times of cardiopulmonary bypass and selective antegrade cerebral perfusion were 227 ± 63 and 64 ± 20 minutes, respectively. Early deaths occurred in 6 (9%), stroke in 5 (8%), and spinal cord injury in 1 (2%). Distal reintervention was required in 22 cases (33%) and freedom from late distal operation was 83 ± 5%, 74 ± 6%, and 47 ± 14% at 1, 5, and 10 years, respectively. Late death occurred in 11 patients (18%) and the overall survival was 88 ± 4%, 72 ± 6%, and 62 ± 9% at 1, 5, and 10 years, respectively [25].

E-vita Open and E-vita Open Plus

The E®-vita Open Plus hybrid prosthesis is an updated version of its predecessor, E-vita Open (Jotec GmBH, Hechingen, Germany). Invented by Dr. Jakob [32], these grafts are similar in design, but the updated version is less blood permeable and obviates the need for pre-sealing with fibrin glue. The E-vita Open Plus is fabricated from a specially texturized polyester yarn and has a water permeability index of 60 mL/min/cm2 in contrast to 650 mL/min/cm2 of the E-vita Open [33].

The hybrid prosthesis consists of a stented portion with a flexible, Z-shaped nitinol wire (13 to 16 cm long, 24 to 40 mm in diameter) covered by a polyester fabric. A proximal nonstented woven graft (5 or 7-cm long) is fixed circumferentially to the proximal end of the stented portion. The proximal and distal grafts are identical in diameter, and a sewing collar is added between them in the latest design to facilitate anastomosis (Figure 3) [34], which is similar to the Vascutek Hybrid. Radiopaque markers are integrated in the graft to permit radiological imaging.

Figure 3.

The E-vita Open Plus hybrid prosthesis and its delivery system [30] (Adapted with permission from Jotec GmbH).


The delivery system consists of a shaft, a grip handle, catheters, a release switch, and a positioning aid. The delivery system is over 100 cm in length and suitable for patients with large statures. The whole prosthesis is placed over a stiff guide wire inserted transfemorally and deployed with a “squeeze-to-release” mechanism, in which the prosthesis will be introduced 4 mm forward into the proximal descending aorta by every “squeeze” of the lever (Figure 3). The deployment of the stented graft is achieved by the retraction of the retaining sheath (see supplemental Video 1 at [35]. The invaginated unstented graft is then pulled back. Distal anastomosis at a level between the left subclavian artery and proximal descending aorta is completed with continuous stitches of 3-0 polypropylene secured with an external Teflon felt strip [35]. The arch branches are reattached end-to-side to the proximal graft using the 3-vessel Carrel patch technique (Figure 4) [36].

Figure 4.

Deployment of E-vita Open Plus and reconstruction of the aortic arch [32] (Adapted with permission from Jotec GmbH).


In retraction of the stented graft, the prosthesis may slide within the aortic lumen, which complicates proper positioning. Difficulties during extraction of the delivery system were also reported in early series [37]. In the latest version, the previous design of solid ballpoint tip is replaced by a balloon tip, which facilitates deployment and reduces injury to the aortic intima [34].

The E-vita Open entered the European market in 2005 and was replaced by E-vita Open Plus, which received a CE mark in June 2014. By December 2015, over 5000 patients were successfully treated [34]. The International E-vita Open registry, which was launched in 2005 [3840], has recruited 575 patients from 10 European centers by August 2014 [41]. Postoperative data was complete in 568 patients, including 211 (37.1%) acute dissections, 187 (32.9%) chronic dissections, and 170 (29.9%) aortic aneurysms, with a mean age of 59, 58, and 67 years, respectively. The times of cardiopulmonary bypass, cross-clamp, and selective antegrade cerebral perfusion were 245, 252, and 220 minutes, 144, 148, and 124 minutes and 66, 88, and 66 minutes, respectively. In-hospital mortality was 18%, 17%, and 12% for each group; permanent stroke occurred in 6%, 1%, and 0; spinal cord injury occurred in 3%, 4%, and 4%, and dialysis in 2%, 5%, and 4%, respectively. Follow-up was completed in 91% (517/568). CT scan was performed in 141, 87, and 89 patients in each group, respectively. At the latest follow-up, complete thrombosis of false lumen was seen in 94% and 86% in patients with acute and chronic dissections, and complete exclusion in 94% of aneurysm patients at the stent graft level. At 5 years, survival was 85%, 79%, and 69% for acute dissection, chronic dissection, and aneurysmal patients. Freedom from endovascular repair was 95%, 73%, and 87%, and freedom from open repair on the downstream aorta was 98%, 91%, and 95%, respectively [41].

Thoraflex Hybrid

Designed by Drs. Haverich, Shrestha, and Pichlmaier, the Thoraflex Hybrid prosthesis (Vascutek, Inchinnan, Scotland, UK) consists of a proximal unstented sealed woven Dacron tube and a distal stented part made of polyester and nitinol stents. The unstented portion has four integrated side branches: three for arch vessel reconstruction and one for distal and antegrade cerebral perfusion. The stented part is 10 or 15 cm in length and 28–40 mm in diameter (Figure 5). The proximal unstented and distal stented segments of the graft are different in diameter. The unstented part is smaller, which allows for space in the arch for branch reconstruction. There is a sewing collar between the proximal and distal segments, which facilitates suturing of the distal anastomosis, especially in patients with aneurysm of the arch and proximal descending aorta (Figure 6). The design with independent, ring-shaped stents not only allows for better arch curvature and anatomic conformity to the descending aorta but also reduces the radial force on the aortic wall, thus minimizing the risk of intimal injury in patients with aortic dissection. Radiopaque markers are incorporated in both the proximal graft and the distal stented portion for radiological visualization. The prosthesis is impregnated with bovine gelatin, which eliminates the need for pre-clotting [42].

Figure 5.

The Thoraflex Hybrid prosthesis and its delivery system (Courtesy of Vascutek, Terumo Cardiovascular Systems, adapted with permission).

Figure 6.

Operative view of the sewing collar of Thoraflex Hybrid after completion of distal anastomosis (Courtesy of Dr. Maximilian Pichlmaier).


The delivery system consists of a central catheter, a malleable stainless steel shaft with outer PTFE splittable sheath, and a handle that is made from a range of molded thermoplastic polyurethane. The stented portion is first bent slightly to fit the curvature of the descending aorta, and may then be advanced down over a stiff guide wire by a side rail technique. The sheath is bisected by pulling it through the splitter using the strap thereby enabling the stent to open. The splitter is then removed to free the sewing collar. Before the delivery system can be removed from the hybrid graft, the tip capture mechanism for placement correction has to be released by pulling the release wire clip at the back of the handle (see supplemental Video 2 at The distal anastomosis is performed with the sewing collar using a 3-0 running polypropylene and may be reinforced with a second layer of pledgeted 3-0 polypropylene. The fourth side branch is cannulated to reperfuse the lower body. The arch vessels are reconnected to the side branches of the proximal unstented graft in an end-to-end fashion (Figure 7), occasionally using bridging stents, Viabahn® (W. L. Gore & Associates, Newark, DE) [43].

Figure 7.

Deployment of Thoraflex Hybrid prosthesis and arch reconstruction (Courtesy of Vascutek, Terumo Cardiovascular Systems, adapted with permission).


The integrated side branches represent a unique and highly valuable feature that allows for separate reconstruction of the arch vessels [44], which may be important in patients with a severely atherosclerotic aortic arch, Marfan syndrome and considerable distance between the origins of the arch vessels. Compared to other straight grafts, the 4-branched graft may reduce the time of lower body and myocardial ischemia, which is generally associated with improved outcomes after complex aortic arch reconstruction [45]. A concern may arise after the anastomosis of the sewing collar to the proximal descending aorta is completed and the graft and side branches are fixed in position [46]. Although the side branches can be cut to desired lengths before anastomosing to the arch vessels to avoid kinking and twisting, at this stage it is difficult to rotate the side branches along the long axis of the aorta, should this be required [37]. Manual deployment of Thorflex hybrid may also be hindered by the four arch branches in the operative field [47]. Its use may also be limited by the aortic anatomy in chronic arch pathologies [48].

The Thoraflex Hybrid received CE mark in November 2012 and there were more than 1180 implants by December 2015 [Mr. Jonathan Hargreaves, Personal communication (email), January 2016]. In the first 100 patients of the Hannover group (65 males, mean age 58.7 ± 13.6 years) as of October 2014 [49], surgical indication was dissection in 57 (38 acute) and aneurysm in 43; there were 11 Marfan patients, 28 redo operations, 40 root procedures, and 12 coronary artery bypasses. The times of cardiopulmonary bypass, cross-clamp, circulatory arrest, and antegrade cerebral perfusion were 241 ± 61, 123 ± 62, 57 ± 35 [49], and 85 ± 39 minutes [25], respectively. Early mortality was 6%. The rates of stroke, re-exploration for bleeding, and spinal cord injury were 10%, 13% [49], and 6% [25], respectively. In follow-up, 19 secondary interventions on the downstream aorta were required (7 open, 12 endovascular) [49]. At 1 year, two late deaths occurred; survival was 77 ± 7% and freedom from distal operation was 73 ± 8% [25]. The Munich group implanted the Thoraflex in 38 patients as of September 2014, including 12 acute Type A (32%), 2 acute Type B (6%), and 14 chronic dissections (36%), and 10 aneurysms (26%). Mean age was 62 ± 12 years, and 24 patients (63%) were male. In-hospital mortality was 18% (7/38). Early morbidities included stroke in 2 cases (5%), phrenic nerve injury in 5 (13%) and permanent dialysis in 2 (5%). No spinal cord injury occurred. Late death occurred in one case (2.6%) and a downstream procedure was required in five (13%) [50]. In the Bologna experience with 11 patients (9 with chronic dissection and 2 aneurysms, age 63 ± 9 years), the time of cardiopulmonary bypass and antegrade cerebral perfusion was 227 ± 98 and 81 ± 29 minutes, respectively; no cases of early death, spinal cord injury, or stroke occurred. Early morbidities included reexploration for bleeding in 2 cases, transient ischemic attack in 1, and renal failure requiring temporary dialysis in 1 [51]. Currently Thoraflex Hybrid is not commercially available in the United States.


The Cronus open stented graft (MircoPort, Shanghai, China) was designed and introduced by Dr. Sun in 2003 [52]. It consists of a regular Dacron vascular tube and interconnected Z-shaped stents made from conichrome (a Co-Cr-Ni-Mo-Fe alloy). At the proximal and distal ends, there is an extra centimeter of Dacron sewing cuff, to which a conventional hand-sewn anastomosis can be performed (Figure 8). The graft is 4–15 cm in length and 21–32 mm in diameter. Compared with other devices, the Cronus is more compact (15–25 cm in full length) due to the avoidance of the unstented portion, which allows for more accurate deployment deep into the operative field of the descending aorta.

Figure 8.

The Cronus open stented graft and its delivery system (Reprinted with permission from Elsevier. Left: Ref [69]; Right: Sun et al. Surgery for Marfan patients with acute Type A dissection using a stented elephant trunk procedure. Ann Thorac Surg. 2008;86:1821-5).


The delivery system consists of a grip handle, a pull wire and a fixation string of 2-0 silk, which holds the prosthesis in a compressed state before deployment. The graft is bent slightly to conform to the arch curvature and inserted into the proximal descending aorta. Deployment simply involves gripping the handle in one hand and pulling out the pull wire with the other hand; the stent graft expands automatically, usually within seconds (see supplemental Video 3 at [53]. Distal anastomosis is located between the left carotid and left subclavian arteries and sutured using continuous stitches of 3-0 or 4-0 polypropylene. The arch vessels are reconnected end-to-end to the branches of a separate, four-branched graft (Figure 9). To minimize the time of cerebral and cardiac ischemia, the left common carotid artery is reconstructed first, then the proximal ascending aorta, followed by the left subclavian and innominate arteries [54, 55].

Figure 9.

Deployment of Cronus and arch reconstruction (Reprinted with permission from Ma WG, et al. Aorta (Stamford) 2013;1:59-64. [54]).


Owing to its technical simplicity, over 18,000 patients have been treated successfully with the Cronus in China and South American countries [56, 57]. In a group of 803 patients with Type A dissection (age 46 ± 11 years), the times of cardiopulmonary bypass, selective antegrade cerebral perfusion, and cross-clamp were 193 ± 51, 24 ± 8, and 106 ± 40 minutes, respectively. Operative mortality was 6.5% (52/803) and the incidences of stroke and spinal cord injury were 2.0% (16/803) and 2.3% (19/803), respectively [17]. In another cohort of 291 patients with Type A dissection followed up for 42 ± 18 months, the overall late mortality was 3.5% (10/291), obliteration of the false lumen around the stented graft occurred in 90.8% (256/282), and reintervention was required in 1.7% (5/291) of patients [58]. In a series of 104 dissection patients with an arch entry tear (excluding retrograde dissections arising from the descending aorta), the operative mortality was 8.6% (9/104). Early morbidity included renal failure in 4 cases (3.8%), spinal cord injury in three (2.9%), stroke in 2 (1.9%), limb ischemia in 2 (1.9%), reexploration for bleeding in 2 (1.9%), and recurrent laryngeal nerve injury in 1(1.0%). Follow-up was complete in 100% for 5.0 ± 2.6 years (range 1.3-11.1). Late death occurred in 2 patients (1.9%). Survival was 88.9% and no late distal reintervention was required at 10 years [59].

J Graft Open Stent Graft

The J Graft open stent graft (Japan Lifeline, Tokyo, Japan) is an updated version of Dr. Kato's previous design [8, 60]. It consists of a distal stented part that is made of a polyester tube with oval shaped nitinol stents, and a proximal unstented graft. The two parts are folded and mounted on a shaft within a soft sheath. J Graft is 21–39 mm in diameter and the stented portion is 6-12 cm in length (Figure 10). The full length of J Graft OSG is 57 cm. Compared with other open stent grafts, one major advantage of the J Graft lies in its unique interconnected double-layered oval-shaped nitinol stents that allow for sliding between two the two layers, which may represent the best design for conforming to the curvature of the aorta [61].

Figure 10.

The J Graft open stent graft and its delivery system (Courtesy of Mr. Makoto Takakura and Mr. Hideki Kataoka from Japan Lifeline, adapted with permission).


The delivery system consists of a 15-cm long grip handle integrated with a shaft, a 2-layer soft sheath attached to a release knob and a fixation string (Figure 10). Before deployment, the stented portion is bent to conform to the curvature of the aorta. In deployment, holding the grip handle in position and pulling back the release knob along with the sheath will release the whole prosthesis (Figure 11) (see supplemental Video 4 at For distal anastomosis, four 4-0 polypropylene stay sutures are placed first, followed by running stiches of 4-0 polypropylene reinforced by a felt strip [62]. The arch vessels are reconstructed with a separate branched graft in an end-to-end fashion [61, 63].

Figure 11.

Deployment of J Graft open stent graft (Courtesy of Mr. Makoto Takakura and Mr. Hideki Kataoka from Japan Lifeline, adapted with permission).


During its premarketing clinical trial from March 2008 to September 2010, the J Graft OSG was implanted in 60 patients [61, 64]. Mean age was 71.6 ± 8.6 years and there were 44 males (73.3%). Surgical indication was aneurysm in 38 (63%) cases, acute Type A dissection in 6 (10%), chronic Type A dissection in 2 (3%), acute Type B in 1 (2%), and chronic Type B in 13 (22%). In-hospital mortality was 5% (3/60) and early morbidities included stroke in 6 (10%) cases, spinal cord injury in 4 (6.7%), and endoleak in 2 (3.3%). At 1 year, late mortality occurred in 10% (6/60) and secondary thoracic endovascular aortic repair was required in 8.3% (5/60), for distal aneurysmal dilation in 2 cases, thoracoabdominal aortic rupture in 1, and distal endoleak and downstream aneurysmal dilation in 2. Kaplan-Meier survival was 78% at 3.8 years (1400 days). The J Graft OSG received commercial approval in Japan in February 2014 [65]. Between July 2014 and December 2015, J Graft was implanted in 2216 patients. Surgical indications were aneurysm in 51%, Type A dissection in 33%, Type B dissection in 10%, aortic rupture in 3%, type Ia endoleak after TEVAR in 2% and Kommerell diverticulum in 1%. According to incomplete data, spinal cord injury occurred in 1.9% (43/2216), including paraparesis in 13 cases (0.6%) and paraplegia in 30 (1.3%). This incidence was much lower than the 6.7% reported in the premarket trial [61], which may be the result of avoidance of implanting below T8, and earlier distal perfusion after delivery of stent graft [Hideki Kataoka. Personal communication (email), January 2016].


From a technical perspective, each of the aforementioned OSGs has its pros and cons (Table 1). For instance, although the Thoraflex and E-vita Open Plus are more sophisticated in design and intended for treating more complex arch and descending pathologies by using a single piece device, their deployment is time consuming and more technically demanding. The stented portion of Thoraflex is not available in sizes of less than 28 mm, which may result in new intimal tears distal to the stent graft, hampering false lumen exclusion and thrombosis in cases of aortic dissections with small or narrowed true lumens [47]. In contrast, the Cronus and J Graft Open are more compact and easier to deploy (no fluoroscopy or guide wires for Cronus), but the Cronus requires a separate proximal graft and is not available in sizes of more than 32 mm for patients with larger aortas. It is important to note that, due to variability in patient and aortic characteristics, the technical merits of each device are difficult to quantify and directly comparing them is even more difficult. An ideal OSG should be capable of successfully treating patients in clinical settings ranging from dissection and aneurysm to associated pathologies like Kommerell diverticulum and coarctation [66, 67]. In addition, an ideal graft should be able to provide satisfactory early and late outcomes for any patient, regardless of etiology [68], anatomy, acuity [48], and patient size, with minimal surgical risks, especially in terms of spinal cord injury, stroke, and endoleak. The “ideal” OSG would also include the following characteristics:

  1. Ease of deployment (and expansion), without increasing technical complexity and prolonging ischemic and perfusion durations

  2. Avoidance of fluoroscopy and guide wires

  3. Firm fixation to the aortic wall without potential for graft migration

  4. High flexibility and conformation to the curvature of the aorta, without kinking or twisting

  5. Biocompatible surface with minimal blood permeability

  6. Tapered distal end to fit well within the descending aorta, especially for patients with chronic dissection

  7. Ease of anastomosis in secondary distal interventions, if such are necessary

Table 1.

Comparison of currently available open stented grafts.

Device E-vita Open (Plus) Thoraflex Hybrid Cronus J Graft Open
Year of marketing 2008 2012 2003 2014
Manufacturer Jotec Vascutek MicroPort Japan Lifeline
Number of implants (by Dec 2015) >5000 >1180 >18000 > 2200
Availability Europe, Asia Pacific Europe, Asia Pacific, Canada China, South America Japan
Technical Aspects
Full length (cm) 18, 22, 23 34, 39 15-25 57
Diameter of stent graft (mm) 24-40 28-40 21-32 21-39
Length of stent graft (cm) 13, 15, 16 10, 15 4-15 6, 9, 12
Proximal and distal diameter Same Different Same Same
Stent design and material Z shaped nitinol Ring shaped nitinol Z shaped conichrome Oval shaped 2-layer nitinol
Arch curvature Fair Better Fair Possibly best
Sewing collar Yes Yes No No
Distal sewing cuff No No 1 cm No
Unstented portion Yes Yes No Yes
Arch and perfusion branches No Yes No No
Delivery method Squeeze and pull Pull, press, pull Pull Pull
Need for positioning Yes No No Yes
Guidewire or X-Ray Necessary Optional No need No need
Blood permeability 60 mL/cm2/min NA NA 150 mL/cm2/min
Method of arch repair Carrel patch technique An integrated 4-branched graft A separate 4-branched graft A separate branched graft
Better indicated in Aneurysm Aneurysm and dissection Dissection Aneurysm
Clinical Outcomes
Patient age (years) 61 59 ± 14 46 ± 11 72 ± 9
Cardiopulmonary bypass time 239 241 ± 61 193 ± 51 178 ± 40
Selective antegrade cerebral perfusion time 71 85 ± 39* 25 ± 9 40 ± 37
Early mortality (%) 15.8 (90/568) 8.7 (13/149)# 6.4 (53/832) 5.0 (3/60)
Early stroke (%) 2.6 (15/568) 8.0 (12/149)# 2.0 (17/832) 10.0 (6/60)
Early spinal cord injury (%) 3.5 (20/568) 4.0 (6/149)# 2.4 (20/832) 6.7 (4/60)
Duration of follow-up (year) 5 1* 5.0 ± 2.6 3.8
Late survival (%) 69-85 77 ± 7* 89 78
Late reintervention (%) 2-27 14.1 (24/149)# 6.5 (69/1063) 8.3 (5/60, 1 yr)

# Calculated based on the reports of Ius, Pichlmaier, Shrestha and Di Marco [25, 4951]

* Ius, et al. [25]

NA = not available.

With the evolution and expanded indications for the FET technique [22, 67, 69, 70], there is a growing need for versatile, technically simple, and highly durable systems involving less complicated deployment mechanisms which enable use in various indications. Because the currently available OSGs have not yet obtained FDA approval in the United States, several modified FET techniques using endovascular stent grafts have been proposed as a “bailout” [7173].

While none of the available OSGs can yet claim to be an ideal device, technology continues to improve towards this goal.

As novel devices and systems are being developed specifically for the FET technique [74, 75] and manufacturers are frequently improving their technology to update their devices, more widespread use can be expected. For example, the 3 zone aortic arch hybrid prosthesis recently designed by Jakob, E-Novia, combines a routine proximal ascending polyester graft in continuity with an uncovered, nitinol stent in the arch portion and a stented graft in the descending aorta [76]. It is aimed at single-stage repair of ascending, arch and descending pathology and preliminary results have been favorable in patients with very high surgical risks [77]. Reports have emerged on the use of branched OSGs with one to three self-expanding stented side branches in an attempt to facilitate distal anastomosis and arch reconstruction [78, 79]. Favorable long-term outcomes have also been achieved with the Matsui-Kitamura stent graft [80].

Continued technologic improvements in FET technology can fairly be expected to result in improved clinical outcomes and quality of life for patients with complex aortic diseases.


This study was supported in part by the National Key Technologies R&D Program (Grant 2015BA112B03) and Special Research Fund for Public Health and Welfare (Grant 201402009). The authors wish to express their sincere gratitude to Dr. Maximilian A. Pichlmaier from Universität München, Germany for his generous and invaluable help in making edits and comments and providing figures for this paper. We are also grateful for Profs. Heinz G. Jakob from Universitätsklinikum Essen - Westdeutsches Herzzentrum and Malakh L. Shrestha from Medizinischen Hochschule Hannover, Germany; Mr. John McKenna and Mr. Jonathon Hargreaves from Vascutek Terumo Cardiovascular Systems, Mr. Makoto Takakura and Mr. Hideki Kataoka from Japan Lifeline Co., Ltd, and Ms. Grace Li from the AME Publishing Company, who gave permission to use and adapt the data, videos, and figures that they have provided.

Conflict of Interest

Dr. Elefteriades is an investigator for the clinical trial of Thoraflex Hybrid in US. The other authors have no conflicts of interest relevant to this publication.


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Cite this article as: Ma W, Zheng J, Sun L, Elefteriades JA. Open Stented Grafts for Frozen Elephant Trunk Technique: Technical Aspects and Current Outcomes. AORTA (Stamford). 2015;3(4):122-135. DOI: 10.12945/j.aorta.2015.14.062

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